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- Table of Contents
Facts about Signal-induced proliferation-associated 1-like protein 1.
Stimulates the GTPase activity of RAP2A.
Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin.Contributes to the regulation of dendritic spine morphogenesis (By similarity). .
Human | |
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Gene Name: | SIPA1L1 |
Uniprot: | O43166 |
Entrez: | 26037 |
Belongs to: |
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No superfamily |
Signal-induced proliferation-associated 1-like protein 1
Mass (kDA):
200.029 kDA
Human | |
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Location: | 14q24.2 |
Sequence: | 14; NC_000014.9 (71320418..71741209) |
Widely expressed.
Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptosome. Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity).
PMID: 9858596 by Gao Q., et al. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation.
PMID: 18094260 by Richter M., et al. The EphA4 receptor regulates neuronal morphology through SPAR- mediated inactivation of Rap GTPases.