Zinc finger protein 423 (ZNF423)

Transcription factor that can both act as an activator or a repressor depending on the circumstance. Plays a central role in BMP signaling and olfactory neurogenesis.

Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor through its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes.