Protrudin (ZFYVE27)

Key regulator of RAB11-dependent vesicular trafficking through neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity).

Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and the density of tubule interconnections (PubMed:23969831).