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- Table of Contents
Facts about Protrudin.
Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and the density of tubule interconnections (PubMed:23969831).
Human | |
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Gene Name: | ZFYVE27 |
Uniprot: | Q5T4F4 |
Entrez: | 118813 |
Belongs to: |
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No superfamily |
FLJ32919; PROTRUDIN; RP11-459F3.2; SPG33; zinc finger FYVE domain-containing protein 27; zinc finger, FYVE domain containing 27
Mass (kDA):
45.843 kDA
Human | |
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Location: | 10q24.2 |
Sequence: | 10; NC_000010.11 (97737121..97760907) |
Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi-pass membrane protein. Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network.
PMID: 17082457 by Shirane M., et al. Protrudin induces neurite formation by directional membrane trafficking.
PMID: 18459960 by Shirane M., et al. Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.