ZBTB48 Antibodies

AND ZBTB48 ELISA kits, ZBTB48 Proteins

Many biological assays use antibodies to detect ZBTB48, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZBTB48 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZBTB48 antibodies...

We validate the specificity of these antibodies to ZBTB48 by testing them on tissues known to express ZBTB48 positively and negatively. Browse below to find the ZBTB48 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZBTB48 Infographic by Boster Bio

All ZBTB48 Products

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Product

Figures

Specificity

Applications

Price

Anti-ZBTB48 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A13220-1
100 μg/vial

ZBTB48 (NM_005341) Human Over-expression Lysate

Human

$628
Cat # LS003104
100 µg

Anti-ZBTB48 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A13220-2
100 μg/vial

ZBTB48 Overview

Facts about Telomere zinc finger-associated protein.

ZBTB48 3D structure. Source: alphafold

Telomere zinc finger-associated protein (ZBTB48)

Telomere-binding protein that functions as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' replicate (PubMed:28500257, PubMed:28082411).

Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also functions as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257).

Gene Information

Human
Gene Name:	ZBTB48
Uniprot:	P10074
Entrez:	3104

Family

Belongs to:

krueppel C2H2-type zinc-finger protein family

Alternative Names

GLI-Kruppel family member HKR3; HKR3zinc finger and BTB domain-containing protein 48; Krueppel-related zinc finger protein 3; Protein HKR3; zinc finger and BTB domain containing 48; Zinc finger protein 855; ZNF855pp9964

Molecular Weight

Mass (kDA):
77.054 kDA

Genomic Context


Human

Location:	1p36.31
Sequence:	1; NC_000001.11 (6579994..6589280)

Tissue Specificity

Detected in adrenal gland and neuroblastoma.

Subcellular Localizations

Nucleus. Chromosome, telomere. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257).

Diseases

Malignant Neoplasms

Interacting Proteins

DVL3
GPATCH2L
KRTAP10-5
NME7
TRIM41

ZBTB8A
ZNF408

Pathways

Localization

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZBTB48

References

PMID: 7969177 by Sugawara M., et al. A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.

PMID: 9516840 by Maris J.M., et al. Human Kruppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene?