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- Table of Contents
Facts about Y-box-binding protein 1.
Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes.
Human | |
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Gene Name: | YBX1 |
Uniprot: | P67809 |
Entrez: | 4904 |
Belongs to: |
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YBX1 family |
BP-8; CBF-A; class II, Y box-binding protein I; CSDA2; CSDB; DBPB CCAAT-binding transcription factor I subunit A; EFI-A; Enhancer factor I subunit A; MDR-NF1; MGC104858; MGC110976; MGC117250; NSEP1 Y-box-binding protein 1; nuclease-sensitive element-binding protein 1; Y box binding protein 1; YB1 DNA-binding protein B; YB-1 Y-box transcription factor; YBX1
Mass (kDA):
35.924 kDA
Human | |
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Location: | 1p34.2 |
Sequence: | 1; NC_000001.11 (42682418..42703805) |
Cytoplasm. Nucleus. Cytoplasmic granule. Secreted. Secreted, extracellular exosome. Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673).
PMID: 2977358 by Sakura H., et al. Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.
PMID: 3174636 by Didier D.K., et al. Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.