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- Table of Contents
Facts about YTH domain-containing family protein 2.
Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs leads to the localization into mRNA decay sites, like processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Needed maternally to regulate oocyte maturation: likely acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity).
Human | |
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Gene Name: | YTHDF2 |
Uniprot: | Q9Y5A9 |
Entrez: | 51441 |
Belongs to: |
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YTHDF2 family |
CLL-associated antigen KW-14; HGRG8YTH domain family 2; High-glucose-regulated protein 8; NY-REN-2,9430020E02Rik; Renal carcinoma antigen NY-REN-2; YTH domain family protein 2; YTH domain family, member 2
Mass (kDA):
62.334 kDA
Human | |
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Location: | 1p35.3 |
Sequence: | 1; NC_000001.11 (28736621..28769775) |
Cytoplasm, cytosol. Nucleus. Cytoplasm, P-body. Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103).
PMID: 22575960 by Dominissini D., et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A- seq.
PMID: 24206186 by Kang H.J., et al. A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae.