XRCC5 Antibodies

X-ray repair cross-complementing protein 5 (XRCC5)

Single-stranded DNA-dependent ATP-dependent helicase.

The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner.

It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6.

Gene Information

Human
Gene Name:	XRCC5
Uniprot:	P13010
Entrez:	7520

Family

Belongs to:
ku80 family

Alternative Names

80kDa; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC85; CTCBF; EC 3.6.4.-; FLJ39089; G22P2; KARP1; KARP-1; Ku80; Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen; Ku86; Ku86DNA repair protein XRCC5; KUB2; NFIV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit; X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross-complementing

Molecular Weight

Mass (kDA):
82.705 kDA

Genomic Context

Human
Location:	2q35
Sequence:	2; NC_000002.12 (216109348..216206293)

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Chromosome.

Diseases

• Neoplasms
• Malignant Neoplasms
• Autoimmune Reaction
• Severe Combined Immunodeficiency
• Carcinoma
• Lupus Erythematosus, Systemic
• Autoimmune Diseases
• Immunologic Deficiency Syndromes
• Genomic Instability
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Ataxia Telangiectasia
• Chromosome Breakage

• Mammary Neoplasms
• Cytogenetic Abnormality
• Leukemia
• Diffuse Scleroderma
• Werner Syndrome
• Ataxia
• Lymphoma

Interacting Proteins

• APLF
• COIL
• GOLPH3
• HOXB7
• HSPB1

• PPM1G
• PRKDC
• TPT1
• XRCC6

Pathways

• Dna Repair
• V(d)j Recombination
• Double-strand Break Repair
• Cell Cycle
• Localization
• Dna Replication
• Telomere Maintenance
• Cell Death
• Cell Proliferation
• Aging
• Senescence
• S Phase
• Hypersensitivity

• Interphase
• Recombinational Repair
• Pathogenesis
• Cell Growth
• Immune Response
• Dna Recombination
• Cell Cycle Arrest

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Demethylation
• Acetylation

• Reduction
• Oxidation
• Biotinylation
• Phosphorothioation
• Ribosylation

Research Areas

• Cancer
• Chromatin Research
• Core ESC-Like Genes
• DNA Double Strand Break Repair
• DNA Repair

• Non-homologous end-joining
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRCC5

Boster Bio Anti-Ku (P70/P80) (Nuclear Marker)

If you haven't yet purchased the Boster Bio Anti-Ku (p70/p80) (Nuclear Marker), then you have not yet experienced the many benefits this product offers. These benefits include submitting results for applications, species and other samples, and earning product credits. All scientists across the globe can access this program. Read on to find out more. Below are a few of the most effective uses for this marker.

Boster Bio Anti-Ku (p70/p80) (Nuclear Marker)

The Ku (p70/p80), nuclear marker is a heterodimer containing 70 and 80 subunits of protein with a kDa. The Ku antigen is a member of an autoantigen group of DNA-proteins that play a role in the process of arranging the genome. While its precise role in cell biology isn't known, it is similar to transcriptional activator protein. It can stimulate transcription by two promoters.

Potential targets for antibody imaging of prostate carcinoma include the Ku70/p80 complex. Initial tests of the antibody (111.In-DTPA–INCA-X) was performed in NMRI-nude animals with prostate cancer xenografts. The antibody was administered intravenously and then pre-administered at various time points. Tissue samples were obtained at 48, 72, and 96 hours after the injection and radioactivity was assessed.