Exportin-5 (XPO5)

XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its busy GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA.

Docking of the complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP into Ran-GDP (triggered by RANBP1 and RANGAP1, respectively) trigger disassembly of the complex and discharge of the cargo from the export receptor.