Exportin-1 (XPO1)

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP).

Docking of the complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex to the cytoplasm, disassembling of the complicated and hydrolysis of Ran-GTP into Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor.