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X-box-binding protein 1 Antibodies
AND XBP1 ELISA kits, X-box-binding protein 1 Proteins
Many biological assays use antibodies to detect X-box-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with X-box-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop X-box-binding protein 1 antibodies...
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XBP1 Infographic by Boster Bio
All XBP1 Products
Product
Figures
Specificity
Applications
Price
Anti-XBP1 Antibody Picoband®
2 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9463
100 μg/vial
Cat # PB9463
100 μg/vial
Anti-XBP1 Rabbit Monoclonal Antibody
1 Citations 5 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00234
100 μl
Cat # M00234
100 μl
Human, Mouse, Rat
ELISA, IF, ICC, WB
$524
Cat # M00234-1
0.1 mg
Cat # M00234-1
0.1 mg
XBP1 Overview
Facts about X-box-binding protein 1.
X-box-binding protein 1 (XBP1)
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues like exocrine pancreas and salivary gland (By similarity).
Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent way (PubMed:20348923).
Gene Information
| Human | |
|---|---|
| Gene Name: | XBP1 |
| Uniprot: | P17861 |
| Entrez: | 7494 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
HTF; TREB5; X-box binding protein 1; X-box-binding protein 1; XBP1; XBP-1; XBP2; XBP2Tax-responsive element-binding protein 5
Molecular Weight
Mass (kDA):
28.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.1|22q12 |
| Sequence: | 22; NC_000022.11 (28794560..28800572, complement) |
Tissue Specificity
Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856).
Subcellular Localizations
Endoplasmic reticulum. Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610).; [Isoform 1]: Nucleus. Cytoplasm. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein. Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at
Diseases
- Endoplasmic Reticulum Stress
- Physiological Stress
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Diabetes Mellitus
- Bipolar Disorder
- Carcinoma
- Multiple Myeloma
- Liver Carcinoma
- Neurodegenerative Disorders
- Malignant Neoplasm Of Breast
- Lymphoma
Interacting Proteins
- ATF6
- CREBZF
- HIF1A
- HM13
Pathways
- Cell Death
- Translation
- Pathogenesis
- Mrna Splicing
- Secretion
- Protein Folding
- Cell Differentiation
- Autophagy
- Cell Cycle
- Transport
- Plasma Cell Differentiation
- Immune Response
- Secretory Pathway
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Oxidation
- Ubiquitination
- Dephosphorylation
Research Areas
- Cancer
- Lipid and Metabolism
- Unfolded Protein Response
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XBP1
bosterbio.com/bosterbio-gene-info-cards/XBP1
References
PMID: 2321018 by Liou H.-C., et al. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
PMID: 2196176 by Yoshimura T., et al. Multiple cDNA clones encoding nuclear proteins that bind to the tax- dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.
2 Publications of Boster X-box-binding protein 1 Antibodies & ELISA Kits
- PubMed ID: 10.1002/tox.20724, Excessive fluoride induces endoplasmic reticulum stress and interferes enamel pr...
- PubMed ID: -, Wang,X.,Xu,X.,Yang,Y. P.,Xin,X.,Li,Z.,Wang,Q. ... Zhang,L.(2021).Dihydromyriceti...
*More publications can be found for each product on its corresponding product page