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- Table of Contents
Facts about Pre-mRNA-splicing regulator WTAP.
Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Human | |
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Gene Name: | WTAP |
Uniprot: | Q15007 |
Entrez: | 9589 |
Belongs to: |
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fl(2)d family |
Female-lethal(2)D homolog; hFL(2)D; KIAA0105DKFZp686F20131; MGC3925; PNAS-132; pre-mRNA-splicing regulator WTAP; putative pre-mRNA splicing regulator female-lethal(2D); Wilms tumor 1 associated protein; Wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein
Mass (kDA):
44.244 kDA
Human | |
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Location: | 6q25.3 |
Sequence: | 6; NC_000006.12 (159726696..159756319) |
Ubiquitously expressed.
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
PMID: 12444081 by Ortega A., et al. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1- associated proteins in alternative pre-mRNA splicing.
PMID: 11001926 by Little N.A., et al. Identification of WTAP, a novel Wilms' tumour 1-associating protein.