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Methylosome protein 50 Antibodies
AND Wdr77 ELISA kits, Methylosome protein 50 Proteins
Many biological assays use antibodies to detect Methylosome protein 50, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Methylosome protein 50 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Methylosome protein 50 antibodies...
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Wdr77 Overview
Facts about Methylosome protein 50.
Methylosome protein 50 (Wdr77)
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for gathering to small nuclear ribonucleoprotein core particles.
Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain- containing proteins and subsequent localization to the meiotic nuage (PubMed:19584108).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Wdr77 |
| Uniprot: | Q99J09 |
| Entrez: | 70465 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Androgen receptor cofactor p44; MEP-50; MEP50Nbla10071; methylosome protein 50; MGC2722; p44; p44/Mep50; RP11-552M11.3; WD repeat domain 77; WD repeat-containing protein 77
Molecular Weight
Mass (kDA):
36.943 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 F2.2 |
| Sequence: | 3; |
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Cell Invasion
- Gliosis
- Prostatic Hyperplasia
- Neurodegenerative Disorders
- Malignant Neoplasm Of Breast
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Neoplasm Invasiveness
- Fallopian Tube Diseases
Pathways
- Localization
- Transport
- Methylation
- Cellular Localization
- Cell Differentiation
- Astrocyte Activation
- Cell Growth
- Protein Secretion
PTMs
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Wdr77
bosterbio.com/bosterbio-gene-info-cards/Wdr77
References
PMID: 16712789 by Furuno K., et al. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.
PMID: 19584108 by Vagin V.V., et al. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.