Protein KIBRA Antibodies

Protein KIBRA (WWC1)

Probable regulator of this Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.

Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of this ERK/MAPK cascade.

Gene Information

Human
Gene Name:	WWC1
Uniprot:	Q8IX03
Entrez:	23286

Family

Belongs to:
WWC family

Alternative Names

FLJ10865; FLJ23369; HBeAg-binding protein 3; KIAA0869HBEBP3; KIBRAHBEBP36; Kidney and brain protein; protein KIBRA; protein WWC1; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1

Molecular Weight

Mass (kDA):
125.301 kDA

Genomic Context

Human
Location:	5q34
Sequence:	5; NC_000005.10 (168291645..168472303)

Tissue Specificity

Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Colocalizes with PRKCZ in the perinuclear region.

Diseases

• Alzheimer's Disease
• Neoplasms
• Memory Disorders
• Cell Transformation, Neoplastic
• Malignant Neoplasms
• Memory Impairment
• Depressive Disorder
• Cognition Disorders
• Leukemia
• Cholangiocarcinoma
• Malignant Neoplasm Of Breast
• Mild Cognitive Disorder
• Neurofibromatoses

• Impaired Cognition
• Tissue Adhesions
• Lymphoid Leukemia
• Melanoma
• Dementia
• Carcinoma
• Pituitary Diseases

Interacting Proteins

• Exoc4

Pathways

• Cell Proliferation
• Cell Migration
• Cognition
• Mitosis
• Localization
• Methylation
• Rna Interference
• Protein Phosphorylation
• Transport
• Brain Development
• Mammary Gland Development
• Cell Division
• Cell Cycle

• Long-term Memory
• Exocytosis
• Centrosome Localization
• Membrane Tubulation
• Lactation
• Gland Development
• Tissue Morphogenesis

PTMs

• Phosphorylation
• Methylation

• Dephosphorylation
• Cleavage

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WWC1

Best Uses Of The WWC1 Marker

This article will focus on Boster Bio and the Product range. We will also discuss custom services as well as BeNeLux deliveries. We recommend that you review our previous articles to learn more about Boster Bio and its offerings. We will also briefly discuss validation of ELISA-kits.

Boster Bio

You should use a high-quality antibody if you intend to use the WWC1 mark to identify the animal's DNA. Boster Bio stocks a variety antigens, including the WWC1 mark. Although this biotin labeled molecule is not yet in commercial production, samples can be obtained within a few weeks or days.

The antibodies from boster bio are highly specific and exhibit excellent affinity for WWC1. The antibody has been tested against more than 250 tissue samples. The antibody exhibits high affinity for and sensitivity towards WWC1. The Boster antibodies have been validated for immunohistochemistry and Western Blotting, and are backed by excellent technical support from BeNeLux distributor Sanbio.

Product range

For a quick answer to the question "What is the best way to test the WWC1 protein?" and to get an idea of what is possible with this specific antibody, check out Boster Bio's Boster Tips. Boster Bio Boster tips will help you maximize the results of your ELISA tests and improve the quality. These tips and guides can also be used to help you choose the best antibodies for your experiment.

The Picokine (tm) platform has high sensitivity ELISA assays that are validated for a variety of samples. The ELISA Kits are validated using over 250 tissue samples. This ensures high accuracy and precision. Boster Bio products are tested quantitatively and qualitatively against untransfected cell line and recombinant protein.

Validation of ELISA kits

The WWC1 biomarker was used to measure osteocalcin (CSF) in cerebrospinal Fluid (CSF). The ELISA test kit detected total bone mineral in CSF. Its final response was 1100 RU. This was consistent with previous research. This is consistent with previous studies.

In the present study, patients with MS, PD, or IDD had higher concentrations of the WWC1 mark in CSF than healthy controls. The diagnostic sensitivity of our ELISA was similar to other commercial ELISA kits. The AUC was calculated separately to account for CIS (MS), and apolipoprotein E. The newly developed ELISA is comparable in diagnostic sensitivity and specificity to commercially available ELISA kit.