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- Table of Contents
Facts about Wilms tumor protein 1-interacting protein.
Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A.
Mouse | |
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Gene Name: | Wtip |
Uniprot: | Q7TQJ8 |
Entrez: | 101543 |
Belongs to: |
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zyxin/ajuba family |
WTIP Wilms tumor 1 interacting protein
Mass (kDA):
42.254 kDA
Mouse | |
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Location: | 7|7 B1 |
Sequence: | 7; |
Expressed in kidney, lung, eye and ovary. In kidney, restricted to podocytes.
PMID: 14736876 by Srichai M.B., et al. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus.
PMID: 15798086 by Rico M., et al. WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment.