This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
WTAP Antibodies
AND WTAP ELISA kits, WTAP Proteins
Many biological assays use antibodies to detect WTAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WTAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WTAP antibodies...
Previous: CCN4
Next: CYTIP
WTAP Infographic by Boster Bio
All WTAP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1815
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1815
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
IHC, WB
$523
Cat # M04296
100 µl
Cat # M04296
100 µl
WTAP Overview
Facts about Pre-mRNA-splicing regulator WTAP.
Pre-mRNA-splicing regulator WTAP (WTAP)
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification which plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863).
Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532).
Gene Information
| Human | |
|---|---|
| Gene Name: | WTAP |
| Uniprot: | Q15007 |
| Entrez: | 9589 |
Family
| Belongs to: |
|---|
| fl(2)d family |
Alternative Names
Female-lethal(2)D homolog; hFL(2)D; KIAA0105DKFZp686F20131; MGC3925; PNAS-132; pre-mRNA-splicing regulator WTAP; putative pre-mRNA splicing regulator female-lethal(2D); Wilms tumor 1 associated protein; Wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein
Molecular Weight
Mass (kDA):
44.244 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q25.3 |
| Sequence: | 6; NC_000006.12 (159726696..159756319) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Diseases
- Neoplasms
- Nephroblastoma
- Malignant Neoplasms
- Carcinoma
- Kidney Neoplasm
- Leukemia
- Malignant Paraganglionic Neoplasm
- Ovarian Neoplasm
- Neoplasm Metastasis
- Glioblastoma
- Adenocarcinoma
- Focal Glomerulosclerosis
- Leukemia, Myelocytic, Acute
Interacting Proteins
- IKZF1
- MAGEA11
- METTL14
- SLIRP
- VPS52
Pathways
- Cell Cycle
- Pathogenesis
- Cell Proliferation
- Glomerular Filtration
- Transport
- Smooth Muscle Cell Proliferation
- Muscle Cell Proliferation
- Gastrulation
- Hypersensitivity
- Sex Determination
- Cell Cycle Arrest
- Spermatogenesis
- Embryo Development
PTMs
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WTAP
bosterbio.com/bosterbio-gene-info-cards/WTAP
References
PMID: 12444081 by Ortega A., et al. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1- associated proteins in alternative pre-mRNA splicing.
PMID: 11001926 by Little N.A., et al. Identification of WTAP, a novel Wilms' tumour 1-associating protein.