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- Table of Contents
Facts about ATPase WRNIP1.
Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination.
Human | |
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Gene Name: | WRNIP1 |
Uniprot: | Q96S55 |
Entrez: | 56897 |
Belongs to: |
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AAA ATPase family |
ATPase WRNIP1; bA420G6.2; EC 3.6.1; FLJ22526; putative helicase RUVBL; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; WHIPRP11-420G6.2
Mass (kDA):
72.133 kDA
Human | |
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Location: | 6p25.2 |
Sequence: | 6; NC_000006.12 (2765341..2786952) |
Ubiquitously expressed.
Nucleus. Cytoplasm. Colocalizes with WRN in granular structures in the nucleus.
PMID: 11301316 by Kawabe Y., et al. A novel protein interacts with the Werner's syndrome gene product physically and functionally.
PMID: 15670210 by Tsurimoto T., et al. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.