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WNK1 Antibodies
AND WNK1 ELISA kits, WNK1 Proteins
Many biological assays use antibodies to detect WNK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WNK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WNK1 antibodies...
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WNK1 Infographic by Boster Bio
All WNK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$540
Cat # EKC2007
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2007
1 kit, containing two 96-well plates and all necessary reagents
WNK1 Overview
Facts about Serine/threonine-protein kinase WNK1.
Serine/threonine-protein kinase WNK1 (WNK1)
Serine/threonine kinase which plays an significant role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Activates SCNN1A, SCNN1B, SCNN1D and SGK1.
Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | WNK1 |
| Uniprot: | Q9H4A3 |
| Entrez: | 65125 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; Erythrocyte 65 kDa protein; HSAN2hereditary sensory neuropathy, type II; HSN2MGC163339; hWNK1; KDP; KDPMGC163341; KIAA0344; Kinase deficient protein; p65; PHA2C; PRKWNK1; PRKWNK1PSK; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein kinase, lysine deficient 1; serine/threonine-protein kinase WNK1; WNK lysine deficient protein kinase 1; WNK1
Molecular Weight
Mass (kDA):
250.794 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.33 |
| Sequence: | 12; NC_000012.12 (752579..911452) |
Tissue Specificity
Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron.
Subcellular Localizations
Cytoplasm.
Diseases
- Hypertensive Disease
- Pseudohypoaldosteronism
- Arthrogryposis Multiplex Congenita, Distal, Type Iia
- Essential Hypertension
- Hereditary Sensory And Autonomic Neuropathies
- Acidosis
- Pseudohypoaldosteronism, Type Ii
- Neoplasms
- Metabolic Acidosis
- Malignant Neoplasms
- Hereditary Sensory Autonomic Neuropathy, Type 2
- Nervousness
Interacting Proteins
- OXSR1
- PPP1CA
- Syt2
Pathways
- Transport
- Ion Transport
- Secretion
- Pathogenesis
- Excretion
- Endocytosis
- Localization
- Ion Homeostasis
- Rna Interference
- Response To Osmotic Stress
- Cell Proliferation
- Chloride Transport
- Cell Growth
PTMs
- Phosphorylation
- Biotinylation
Research Areas
- Protein Kinase
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WNK1
bosterbio.com/bosterbio-gene-info-cards/WNK1
References
PMID: 11571656 by Verissimo F., et al. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
PMID: 22701532 by Vidal-Petiot E., et al. A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms.