Wee1-like protein kinase 2 (Wee2)

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence in dictyate prophase I, by phosphorylating CDK1 in'Tyr-15', leading to inhibit CDK1 activity and protect against meiotic reentry.

Also required for metaphase II exit during egg activation by phosphorylating CDK1 in'Tyr-15', to guarantee exit from meiosis in oocytes and promote pronuclear formation. .