Wdr62 Antibodies

AND Wdr62 ELISA kits, Wdr62 Proteins

Many biological assays use antibodies to detect Wdr62, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wdr62 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wdr62 antibodies...

We validate the specificity of these antibodies to Wdr62 by testing them on tissues known to express Wdr62 positively and negatively. Browse below to find the Wdr62 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Wdr62 Infographic by Boster Bio

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WDR62 (NM_001083961) Human Over-expression Lysate

Human

$960
Cat # LS284403
100 µg

Wdr62 Overview

Facts about WD repeat-containing protein 62.

WD repeat-containing protein 62 (Wdr62)

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity).

Plays a role in mother-centriole-dependent centriole duplication; the role looks also to involve CEP152, CDK5RAP2 and CEP63 via a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). .

Gene Information

Mouse
Gene Name:	Wdr62
Uniprot:	Q3U3T8
Entrez:	233064

Family

Belongs to:

No superfamily

Alternative Names

C19orf14MGC166976; chromosome 19 open reading frame 14; DKFZP434J046; DKFZp686G1024; EC 2.7.11.1; EC 2.7.7.38; FLJ33298; WD repeat domain 62; WD repeat-containing protein 62

Molecular Weight

Mass (kDA):
167.283 kDA

Genomic Context


Mouse

Location:	7\|7 B1
Sequence:	7;

Tissue Specificity

Prominent in neural crest lineages from embryonic day (E) 9.5 to E11.5. Also expressed in the ventricular and subventricular zones during the period of cerebral cortical neurogenesis (E11.5-E16.5), with expression decreasing in intensity by E17.5 In the cerebellum, it is strongly expressed in precursors of granule neurons at late embryonic and early postnatal stages; by postnatal day 9 (P9). Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level).

Diseases

Microcephaly
Primary Microcephaly
Congenital Anomaly Of Brain
Malformations Of Cortical Development
Lissencephaly
Hypoplasia
Congenital Cerebellar Hypoplasia
Schizencephaly
Pachygyria
Polymicrogyria
Classical Lissencephalies And Subcortical Band Heterotopias
Craniofacial Abnormalities

Heart Block
Dysplasia
Congenital Heart Defects
Hereditary Diseases
Protein Truncation Abnormality
Severe Mental Retardation

Pathways

Mitosis
Neurogenesis
Localization
Cell Proliferation
Signal Transmission
Transport
Dna Repair
Cell Fate Determination
Metaphase
Myelination
Cell Division

Asymmetric Cell Division
Cell Cycle
Spindle Organization
Chromosome Condensation
Pathogenesis

PTMs

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Wdr62

References

PMID: 20729831 by Bilguvar K., et al. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.