WDR1 Antibodies

WD repeat-containing protein 1 (WDR1)

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Involved in cytokinesis.

Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization.

Gene Information

Human
Gene Name:	WDR1
Uniprot:	O75083
Entrez:	9948

Family

Belongs to:
WD repeat AIP1 family

Alternative Names

Actin-interacting protein 1; AIP1; NORI-1; WD repeat domain 1; WD repeat-containing protein 1

Molecular Weight

Mass (kDA):
66.194 kDA

Genomic Context

Human
Location:	4p16.1
Sequence:	4; NC_000004.12 (10074339..10116860, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, podosome. Cell junction.

Diseases

• Malignant Neoplasms
• Neoplasms
• Pain
• Noise-induced Hearing Loss
• Inflammation
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Carcinoma
• Cell Invasion
• Schizophrenia
• Nematode Infections
• Atherosclerosis
• Fanconi Anemia

• Mood Disorders
• Hyperhomocysteinemia
• Cardiac Complication
• Carcinogenesis
• Cardiovascular Diseases
• Neoplasm/cancer Invasiveness
• Hemorrhage

Pathways

• Localization
• Transport
• Cell Cycle
• Regeneration
• Cell Migration
• Electron Transport
• Immune Response
• Anaphase
• Cytokinesis
• Leukocyte Activation
• Cell Division
• Reverse Transcription
• Cell Motility

• Chromosome Breakage
• Spindle Assembly Checkpoint
• Spindle Assembly
• G2 Phase
• Mitosis
• Ion Transport
• Dna Repair

PTMs

• Cleavage

• Phosphorylation

Research Areas

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR1

Best Uses Of The WDR1 Marker

When it comes to flow cytometry, a single antibody can detect a wide variety of proteins, such as proteins and antigens on cells. Boster offers a wide range of monoclonal and polyclonal primary antibodies with excellent affinity and a long history of citations. Their antibodies are highly useful in research and have been used for more than 25 years.

Steven Boster

One of the most interesting uses of the WDR1 marker is to mark Steven Boster's burial site in Wisconsin. He was a longtime member of the Wisconsin Deer Registry. He passed away after a long battle with COVID-19. Boster is survived by his family including his son Jonathan and grandson Cory. His family lives in Herrin, IL. In honor of Boster, a memorial service was held in his hometown.

His primary antibodies

The WDR1 protein is found on many human cancers and its presence in the cell membrane is an excellent indicator of a variety of diseases. Although a low-strength histidine monoclonal antibody (hsa) is available, its lack of specificity in detecting HDs and other cancers makes it difficult to identify the cause of the disease. This marker, which recognizes a molecule that binds to the cell membrane, is not suitable for in vitro diagnostic tests.

The WDR1 marker is a potential biomarker for AS diseases. It was recently found that serum levels of BRAT1-Ab and WDR1-Ab are significantly associated with poor outcomes in ESCC. These antibodies also correlate with platelet counts. Consequently, BRAT1 upregulation may be an effective biomarker for AS diseases and may help delay the progression of the disease. These results support the routine clinical application of liquid biopsy to diagnose AS and cancer.

Among the different types of brain cancer, the WDR1-Ab is most useful in detecting asymptomatic disease. Currently, this antibody is available for diagnostic and prognostic purposes. However, it can also be used for monitoring and assessing the progression of existing diseases. However, in cases of suspected brain tumors, the WDR1 marker is only useful if it has been detected in the bloodstream of the patient.

Molecular studies of the WDR1 protein suggest that it plays a role in regulating the inflammatory response of neutrophils and apoptosis in megakaryocytes. Using HEK293T cells, researchers studied the Wdr1 gene and found that overexpressed Keap1 protein with endogenous Wdr1 was associated with increased BMDM differentiation. In addition, HNE treatment reduced this association.

His citations

The WDR1 gene regulates cell migration and proliferation through the YAP protein. This protein acts as a relay for the actin cytoskeleton's reorganization to the gene transcription program. WDR1 has also been implicated in the development of several malignancies. Its overexpression in cancer cells may be a potential cause of the disease. His citations for the WDR1 marker have received substantial attention in the scientific literature.