WD repeat and FYVE domain-containing protein 1 (WDFY1)

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1.

Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, in addition to the creation of IFN-beta and inflammatory cytokines (PubMed:25736436).

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