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- Table of Contents
Facts about WD repeat and FYVE domain-containing protein 1.
Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1.
Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, in addition to the creation of IFN-beta and inflammatory cytokines (PubMed:25736436)..
Human | |
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Gene Name: | WDFY1 |
Uniprot: | Q8IWB7 |
Entrez: | 57590 |
Belongs to: |
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No superfamily |
FENS-1Zinc finger FYVE domain-containing protein 17; KIAA1435; Phosphoinositide-binding protein 1; WD repeat and FYVE domain containing 1; WD repeat and FYVE domain-containing protein 1; WD40 and FYVE domain containing 1; WDF1WD40- and FYVE domain-containing protein 1; ZFYVE17phosphoinositide-binding protein SR1
Mass (kDA):
46.324 kDA
Human | |
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Location: | 2q36.1 |
Sequence: | 2; NC_000002.12 (223875348..223945335, complement) |
Early endosome.
PMID: 11739631 by Ridley S.H., et al. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
PMID: 19296456 by He J., et al. Membrane insertion of the FYVE domain is modulated by pH.