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WASF1 Antibodies
AND WASF1 ELISA kits, WASF1 Proteins
Many biological assays use antibodies to detect WASF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WASF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WASF1 antibodies...
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WASF1 Infographic by Boster Bio
All WASF1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1598
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1598
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2135
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2135
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A02114Y125-1
100ul
Cat # A02114Y125-1
100ul
WASF1 Overview
Facts about Wiskott-Aldrich syndrome protein family member 1.
Wiskott-Aldrich syndrome protein family member 1 (WASF1)
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments.
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization through its interaction with the Arp2/3 complex (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | WASF1 |
| Uniprot: | Q92558 |
| Entrez: | 8936 |
Family
| Belongs to: |
|---|
| SCAR/WAVE family |
Alternative Names
KIAA0269WAVEhomology of dictyostelium scar 1; Protein WAVE-1; SCAR1; SCAR1WASP family protein member 1; Verprolin homology domain-containing protein 1; WAS protein family, member 1; WASF1; WASP1; WAVE1; WAVE1FLJ31482; wisk
Molecular Weight
Mass (kDA):
61.652 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (110099819..110180004, complement) |
Tissue Specificity
Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction, focal adhesion. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity).
Diseases
- Wiskott-aldrich Syndrome
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Invasiveness
- Protrusion
- Leukemia
- Tissue Adhesions
- Spinocerebellar Ataxia, Autosomal Recessive 1
- Neoplasm Metastasis
- Vaccinia
- Melanoma
Interacting Proteins
- NCK2
- PFN1
- TRIP10
Pathways
- Cell Migration
- Cell Proliferation
- Localization
- Rna Interference
- Cell Motility
- Pathogenesis
- Endocytosis
- Actin Nucleation
- Transport
- Cell Adhesion
- Platelet Aggregation
- Cytoskeleton Organization
- Cell Cycle
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WASF1
bosterbio.com/bosterbio-gene-info-cards/WASF1
References
PMID: 9732292 by Bear J.E., et al. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
PMID: 9889097 by Machesky L.M., et al. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.