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WAS Antibodies
AND WAS ELISA kits, WAS Proteins
Many biological assays use antibodies to detect WAS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WAS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WAS antibodies...
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WAS Infographic by Boster Bio
All WAS Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1597
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1597
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2134
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2134
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M10788
100 μl/vial
Cat # M10788
100 μl/vial
WAS Overview
Facts about Wiskott-Aldrich syndrome protein.
Wiskott-Aldrich syndrome protein (WAS)
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905).
Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809).
Gene Information
| Human | |
|---|---|
| Gene Name: | WAS |
| Uniprot: | P42768 |
| Entrez: | 7454 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
IMD2THC; Thrombocytopenia 1; WAS; WASP; WiskTHC1; wiskthrombocytopenia 1 (X-linked)
Molecular Weight
Mass (kDA):
52.913 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.23 |
| Sequence: | X; NC_000023.11 (48683753..48691427) |
Tissue Specificity
Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
Subcellular Localizations
Cytoplasm, cytoskeleton. Nucleus.
Diseases
- Wiskott-aldrich Syndrome
- Immunologic Deficiency Syndromes
- Eczema
- Infective Disorder
- Tissue Adhesions
- Primary Immune Deficiency Disorder
- Malignant Neoplasms
- Autoimmune Reaction
- Autoimmune Diseases
- Autoimmunity
- Severe Congenital Neutropenia
- Hereditary Diseases
- Hemorrhage
Interacting Proteins
- ABI3
- APPBP2
- BTK
- CDC42
- CTTN
- HCK
- Hck
- NCK2
- SNX33
- SNX9
Pathways
- Cell Activation
- Cell Motility
- Localization
- T Cell Activation
- Actin Nucleation
- Chemotaxis
- Phagocytosis
- Secretion
- Pathogenesis
- Cell Migration
- Translation
- Endocytosis
- Cell Adhesion
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WAS
bosterbio.com/bosterbio-gene-info-cards/WAS
References
PMID: 8069912 by Derry J.M.J., et al. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.
PMID: 7753869 by Kwan S.-P., et al. Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene.