Vinculin Antibodies

Vinculin (VCL)

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing from the E-cadherin complex.

May also play significant roles in cell morphology and locomotion. .

Gene Information

Human
Gene Name:	VCL
Uniprot:	P18206
Entrez:	7414

Family

Belongs to:
vinculin/alpha-catenin family

Alternative Names

CMD1W; CMH15; metavinculin; MVCL; VCL; Vinculin

Molecular Weight

Mass (kDA):
123.799 kDA

Genomic Context

Human
Location:	10q22.2
Sequence:	10; NC_000010.11 (73998116..74121363)

Tissue Specificity

Metavinculin is muscle-specific.

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.

Diseases

• Tissue Adhesions
• Male Infertility
• Infertility
• Malignant Neoplasms
• Neoplasms
• Cell Invasion
• Von Willebrand Disease
• Cardiomyopathies
• Thrombus
• Neoplasm Metastasis
• Headache
• Edema

• Dental Plaque
• Cardiomyopathy, Dilated
• Hypertrophy
• Carcinoma
• Hemorrhage
• Arachnidism
• Oligospermia

Interacting Proteins

• ARPC2
• CTNNA1
• TEKT1

Pathways

• Sperm Motility
• Fertilization
• Insemination
• Acrosome Reaction
• Cell Adhesion
• Swimming
• Cell Motility
• Pathogenesis
• Localization
• Secretion
• Platelet Aggregation
• Spermatogenesis
• Cell Proliferation

• Transport
• Cell Migration
• Ovulation
• Wound Healing
• Sperm Capacitation
• Regeneration
• Hatching

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation

• Biotinylation
• Methylation
• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VCL

Best Uses of the VCL Marker by Boster Bio

In this article, we'll be discussing the Vinculin/VCL anti-body produced by Boster Bio. We'll look at the applications and benefits of this product, and also troubleshooting. This article will highlight the benefits of this product in various scientific researches, including vet research. This article is applicable to all scientists throughout the world. Here are the top uses for The VCL Marker, as well as the benefits and applications they provide.

Boster Bio's Vinculin/VCL Antibody

The Vinculin/VCL anti-body antibody from Boster Bio is a monoclonal antigen that reacts with Human, Mouse, and Rat. This antibody is highly specific in detecting this protein since it specifically recognizes the Cytoskeletal protein. This anti-body can be used with all other Boster products, such as the Boster Vinculin/VCL antibody marker.

Applications

You must submit an application to the VCL marker to be granted it. This certification is available online. The online application form just requires your contact information, which means it's a breeze to fill out. Although the entire process can take at minimum one year, it is vital that you provide details that have been in active use for at least one to three years. If you decide to alter your contact information after this, you should update your contact information.

There are a variety of useful functions built into the VCL marker. These functions can be used to transmit requests and responses to servers in the backend. Access to bereq is also provided via the VCL marker * variables that are able to return fetch fetch, abandon and deliver. The following examples demonstrate the usage of the VCL marker in web-based applications. It can be used to store and transfer data from any backend , and to manage the speed of your website.

A VCL subroutine is identical to its parent. Varnish's built-in VCL is implicitly concatenated. It provides read, write, delete access to any variable. The variables in the VCL program are often described as the "backend" or the "client" and the names are usually shortened versions of the vcl_* method. When a VCL subroutine is called it receives a string which defines the type of request.

The next step in the process is to decide which location to put the VCL marker. The VCL marker must be erected on the property of another person. The application must be made electronically at the CHC and approved the CHC. In certain instances there is a marker review committee for larger counties. The committee is comprised of people who are interested in setting up the VCL marker. If you've got a marker in your city, you are able to use this application as a guide.

Benefits

The VCL marker is an essential regulator of cell adhesion. It is located in the cytoplasmic area of cell-cell adhesions and regulates multiple biological processes such as apoptosis and mobility. It binds to A-actinin and also stimulates the formation of cell junctions that are specialized. It has many benefits such as the capacity to treat aging, cancer as well as other diseases.

Troubleshooting

You might be wondering what you can do if Markers aren't showing after you have installed VCL on your site. First, check that the XML data directory that contains Markers is capable of being writable. If it does not you might have to create it before trying to solve the issue. These are the most frequent reasons why Markers don't display.

In case the problem persists then try flushing or removing your cache. Your web hosting provider may have enabled caching. Exclude XML files from your CDN option if they're not supported by your CDN option. Refresh your page to ensure that the Marker is displayed correctly. This could resolve the problem. If not, you'll need to contact your web hosting provider. This article explains troubleshooting the VCL Marker.