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- Table of Contents
Facts about Guanine nucleotide exchange factor VAV3.
Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is vital for EFNA1- induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Human | |
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Gene Name: | VAV3 |
Uniprot: | Q9UKW4 |
Entrez: | 10451 |
Belongs to: |
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No superfamily |
FLJ40431; guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Mass (kDA):
97.776 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (107571161..107965180, complement) |
Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.
PMID: 9705494 by Trenkle T., et al. Non-stoichiometric reduced complexity probes for cDNA arrays.
PMID: 10523675 by Movilla N., et al. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.