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VAMP8 Antibodies
AND VAMP8 ELISA kits, VAMP8 Proteins
Many biological assays use antibodies to detect VAMP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VAMP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VAMP8 antibodies...
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VAMP8 Infographic by Boster Bio
All VAMP8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02338
100 μl
Cat # M02338
100 μl
VAMP8 Overview
Facts about Vesicle-associated membrane protein 8.
Vesicle-associated membrane protein 8 (VAMP8)
SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complicated, an extended, parallel four alpha-helical package that drives membrane fusion.
VAMP8 is a SNARE involved in autophagy during the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complicated (PubMed:23217709, PubMed:25686604). Plays also a function in regulated enzyme secretion in pancreatic acinar cells (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | VAMP8 |
| Uniprot: | Q9BV40 |
| Entrez: | 8673 |
Family
| Belongs to: |
|---|
| synaptobrevin family |
Alternative Names
EDB; EDBVAMP-8; Endobrevin; VAMP8; VAMP-8; vesicle-associated membrane protein 8 (endobrevin); vesicle-associated membrane protein 8
Molecular Weight
Mass (kDA):
11.438 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p11.2 |
| Sequence: | 2; NC_000002.12 (85577535..85582031) |
Tissue Specificity
Platelets.
Subcellular Localizations
Lysosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By
Diseases
- Pancreatitis
- Inflammation
- Coronary Heart Disease
- Neoplasms
- Diabetes Mellitus
- Heart Diseases
- Tumor Angiogenesis
- Malignant Neoplasms
- Cystic Fibrosis
- Infarction
- Myocardial Infarction
- Atherosclerosis
- Fibrosis
Interacting Proteins
- SNAP29
- STX17
Pathways
- Exocytosis
- Secretion
- Membrane Fusion
- Transport
- Cytokinesis
- Localization
- Secretory Pathway
- Abscission
- Phagocytosis
- Hemostasis
- Endocytosis
- Vesicle Fusion
- Cell Proliferation
PTMs
- Cleavage
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VAMP8
bosterbio.com/bosterbio-gene-info-cards/VAMP8
References
PMID: 9614193 by Wong S.H., et al. Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.
PMID: 12130530 by Polgar J., et al. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.