Ubiquitin carboxyl-terminal hydrolase 36 (USP36)

Required for cell and organism viability. Plays an essential role in ribosomal RNA processing and protein synthesis, which can be mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402).

Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC from the nucleolus, resulting in prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) from the nucleolus and counteracting ubiquitination of MYC from the SCF(FBW7) complex.