Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin or NEDD8.

Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling.