Ubiquilin-1 Antibodies

AND UBQLN1 ELISA kits, Ubiquilin-1 Proteins

Many biological assays use antibodies to detect Ubiquilin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ubiquilin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ubiquilin-1 antibodies...

We validate the specificity of these antibodies to Ubiquilin-1 by testing them on tissues known to express UBQLN1 positively and negatively. Browse below to find the UBQLN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBQLN1 Infographic by Boster Bio

All UBQLN1 Products

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Product

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Specificity

Applications

Price

Anti-Ubiquilin1 Antibody (Center)

Human, Mouse

IF, IHC-P, WB

$299
Cat # A00823
80 µl

Ubiquilin (UBQLN1) (NM_013438) Human Over-expression Lysate

Human

$628
Cat # LS029979
100 µg

UBQLN1 Overview

Facts about Ubiquilin-1.

UBQLN1 3D structure. Source: alphafold

Ubiquilin-1 (UBQLN1)

Plays an important role in the regulation of distinct protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (through UBA domain) for their polyubiquitin chains and by interacting (through ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878).

Plays a role in the ERAD pathway through its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and might form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672).

Gene Information

Human
Gene Name:	UBQLN1
Uniprot:	Q9UMX0
Entrez:	29979

Family

Belongs to:

No superfamily

Alternative Names

DA41; DA41FLJ90054; DSK2; hPLIC-1; PLIC1; PLIC-1; PLIC-1UBQN; Protein linking IAP with cytoskeleton 1; Ubiquilin 1; ubiquilin-1; UBQLN1; UBQN; XDRP1

Molecular Weight

Mass (kDA):
62.519 kDA

Genomic Context


Human

Location:	9q21.32\|9q21.2-q21.3
Sequence:	9; NC_000009.12 (83659968..83707979, complement)

Tissue Specificity

Brain (at protein level) (PubMed:18953672). Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney.

Subcellular Localizations

Cytoplasm. Nucleus. Endoplasmic reticulum. Cytoplasmic vesicle, autophagosome. Cell membrane. Detected in neuronal processes and at synapses (By similarity). Recruited to the ER during ER-associated protein degradation (ERAD) (PubMed:19822669). Isoform 1 and isoform 3 colocalize with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes (PubMed:21143716). Colocalizes with ORAI1 and TICAM1 in the autophagosome (PubMed:23307288, PubMed:21695056). Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with