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Protein UXT Antibodies
AND UXT ELISA kits, Protein UXT Proteins
Many biological assays use antibodies to detect Protein UXT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein UXT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein UXT antibodies...
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UXT Overview
Facts about Protein UXT.
Protein UXT (UXT)
Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to modulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289).
Together with URI1, associates with chromatin into the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation to the cytoplasm (PubMed:28106301).
Gene Information
| Human | |
|---|---|
| Gene Name: | UXT |
| Uniprot: | Q9UBK9 |
| Entrez: | 8409 |
Family
| Belongs to: |
|---|
| UXT family |
Alternative Names
Androgen receptor trapped clone 27 protein; ART-27protein UXT; SKP2-associated alpha PFD 1; STAP1; Ubiquitously expressed transcript protein; ubiquitously-expressed transcript
Molecular Weight
Mass (kDA):
18.246 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.23 |
| Sequence: | X; NC_000023.11 (47651792..47659180, complement) |
Tissue Specificity
Ubiquitous (PubMed:10087202, PubMed:11854421, PubMed:17635584, PubMed:11827465). Expressed in prostate epithelial cells (PubMed:21730289). Expressed in mammary epithelial cells (PubMed:28106301). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus (PubMed:11854421, PubMed:17635584, PubMed:11827465). Overexpressed in a number of tumor tissues (PubMed:11854421, PubMed:16221885, PubMed:28106301).
Subcellular Localizations
[Isoform 1]: Cytoplasm.; Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Predominantly localizes to the nucleus (PubMed:16221885). Localizes to spindle pole during mitosis (PubMed:16221885).
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Sclerosis
- Primary Lateral Sclerosis
- Neuromuscular Diseases
- Hepatitis B
- Down Syndrome
- Amyotrophic Lateral Sclerosis
Interacting Proteins
- ESR1
- KRT31
- KRT40
- KRTAP10-7
- KRTAP10-8
- MECOM
- NOTCH2NL
- PAK5
- PFDN2
- RELA
Pathways
- Lactation
- Cell Death
- Rna Interference
- Cell Proliferation
- Parturition
- Cell Cycle
- Cell Growth
- Pathogenesis
- Transport
- Cell Cycle Arrest
- Cytokinesis
- Nuclear Transport
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UXT
bosterbio.com/bosterbio-gene-info-cards/UXT
References
PMID: 10087202 by Schroer A., et al. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue.
PMID: 11854421 by Markus S.M., et al. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus.