USP8 Antibodies

AND USP8 ELISA kits, USP8 Proteins

Many biological assays use antibodies to detect USP8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP8 antibodies...

We validate the specificity of these antibodies to USP8 by testing them on tissues known to express USP8 positively and negatively. Browse below to find the USP8 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USP8 Infographic by Boster Bio

All USP8 Products

Product

Figures

Specificity

Applications

Price

Anti-USP8 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A02626
100ul

USP8 (NM_005154) Human Recombinant Protein

$1249
Cat # PROTP40818
20 µg

USP8 (NM_005154) Human Over-expression Lysate

Human

$960
Cat # LS009101
100 µg

USP8 Overview

Facts about Ubiquitin carboxyl-terminal hydrolase 8.

USP8 3D structure. Source: alphafold

Ubiquitin carboxyl-terminal hydrolase 8 (USP8)

Hydrolase that may remove conjugated ubiquitin from proteins and therefore plays an important regulatory function at the level of protein turnover by preventing degradation. Catalytic activity is enhanced in the M phase.

Involved in cell proliferation. Required to enter into S phase in response to serum stimulation.

Gene Information

Human
Gene Name:	USP8
Uniprot:	P40818
Entrez:	9101

Family

Belongs to:

peptidase C19 family

Alternative Names

Deubiquitinating enzyme 8; EC 3.1.2.15; EC 3.4.19.12; HumORF8; KIAA0055hUBPy; MGC129718; ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; ubiquitin specific peptidase 8; ubiquitin specific protease 8; ubiquitin thioesterase 8; Ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8; UBPY; UBPYFLJ34456; USP8

Molecular Weight

Mass (kDA):
127.523 kDA

Genomic Context


Human

Location:	15q21.2
Sequence:	15; NC_000015.10 (50424359..50514421)

Subcellular Localizations

Cytoplasm. Nucleus. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Infertility
Malignant Paraganglionic Neoplasm
Stasis
Neoplasm Metastasis
Infectious Mononucleosis
Malignant Neoplasm Of Breast
Sequelae Aspects
Malignant Tumor Of Cervix
Multiple Myeloma
Tumor Angiogenesis

Nervousness
Mammary Neoplasms
Chimera Disorder
Ovarian Neoplasm
Cell Invasion
Glioblastoma Multiforme

Interacting Proteins

CHMP1A
CHMP1B
CHMP4C
EPAS1
HIF1A

NBR1
YWHAZ

Pathways

Endocytosis
Localization
Transport
Cell Proliferation
Rna Interference
Spermatogenesis
Cell Division
Acrosome Assembly
Cell Growth
Protein Ubiquitination
Endosomal Transport
Cellular Homeostasis
Fertilization

Mitosis
Neurogenesis
M Phase
Cytokinesis
Rna Splicing
Translation
Cell Differentiation

PTMs

Ubiquitination
Phosphorylation

Cleavage
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP8

References

PMID: 9628861 by Naviglio S., et al. UBPY: a growth-regulated human ubiquitin isopeptidase.

PMID: 16520378 by Row P.E., et al. The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.