Ubiquitin carboxyl-terminal hydrolase 3 (USP3)

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry.

May regulate the DNA damage response (DDR) checkpoint via deubiquitination of H2A at DNA damage sites. Associates with the chromatin.