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USP20 Antibodies
AND USP20 ELISA kits, USP20 Proteins
Many biological assays use antibodies to detect USP20, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP20 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP20 antibodies...
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USP20 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 20.
Ubiquitin carboxyl-terminal hydrolase 20 (USP20)
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).
Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it's likely transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP20 |
| Uniprot: | Q9Y2K6 |
| Entrez: | 10868 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 20; EC 3.4.19.12; KIAA1003hVDU2; LSFR3A; pVHL-interacting deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific peptidase 20; ubiquitin specific protease 20; ubiquitin thioesterase 20; Ubiquitin Thiolesterase 20; Ubiquitin-specific-processing protease 20; USP20; VDU2; VHL-interacting deubiquitinating enzyme 2
Molecular Weight
Mass (kDA):
102.003 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.11 |
| Sequence: | 9; NC_000009.12 (129835417..129881838) |
Subcellular Localizations
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
Diseases
- Neoplasms
- Von Hippel-lindau Syndrome
- Adult T-cell Lymphoma/leukemia
- Leukemogenesis
- Leukemia
- Oncogene Activation Process
- Leukemia, T-cell
- Hypoxia
- Hematopoietic Neoplasms
- Malignant Paraganglionic Neoplasm
- Acute Lymphocytic Leukemia
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
Interacting Proteins
- ALAS1
- BEND5
- CCDC36
- FATE1
- MDFI
- SPRY2
- TRIM23
Pathways
- Brain Development
- Response To Hypoxia
- Endocytosis
- Conjugation
- Localization
- Translation
- Cell Cycle
- Cellular Localization
- Cell Growth
PTMs
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP20
bosterbio.com/bosterbio-gene-info-cards/USP20
References
PMID: 12056827 by Li Z., et al. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.
PMID: 10369878 by Gilley J., et al. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.