USP16 Antibodies

Ubiquitin carboxyl-terminal hydrolase 16 (USP16)

Specifically deubiquitinates'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis.

In resting B- and T- lymphocytes, phosphorylation by AURKB contributes to enhance its activity, thereby keeping transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination.

Gene Information

Human
Gene Name:	USP16
Uniprot:	Q9Y5T5
Entrez:	10600

Family

Belongs to:
peptidase C19 family

Alternative Names

Deubiquitinating enzyme 16; EC 3.1.2.15; EC 3.4.19.12; human ubiquitin processing protease, EC 3.1.2.1510ubiquitin specific protease 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific peptidase 16; ubiquitin thioesterase 16; Ubiquitin thiolesterase 16; Ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; Ubiquitin-specific-processing protease 16; UBP-M

Molecular Weight

Mass (kDA):
93.57 kDA

Genomic Context

Human
Location:	21q21.3
Sequence:	21; NC_000021.9 (29024617..29054488)

Tissue Specificity

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Nucleus.

Diseases

• Trisomy 8
• Myelomonocytic Leukemia
• Carcinoma
• Carcinogenesis
• Nonalcoholic Steatohepatitis
• Insulin Resistance
• Malignant Neoplasms
• Neoplasms
• Leukemia, Myelomonocytic, Chronic
• Hematological Disease
• Cytogenetic Abnormality
• Dysmyelopoietic Syndromes
• Fatty Liver

• Adenocarcinoma
• Hyperplastic Polyp
• Lung Neoplasms
• Steatohepatitis
• Cholecystolithiasis
• Neurofibromatosis 1
• Myeloproliferative Disease

Pathways

• Mitosis
• Cell Cycle
• Cell Growth
• Transport
• Histone Ubiquitination
• Regulation Of Cell Cycle
• Gene Silencing
• Proteolysis
• Regulation Of Gene Expression

• Chromosome Segregation
• Conjugation
• Nuclear Transport
• Cell Division

PTMs

• Phosphorylation
• Ubiquitination
• Carboxylation

• Cleavage
• Methylation
• Dephosphorylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP16

Boster Bio - Best Uses Of The USP16 Marker

As an aspiring biologist, you're probably wondering if Boster Bio is the right choice for you. This article will give you some information on the Boster Bio USP16 marker. The USP16 marker is a special type of chemical that can help you determine whether or not a biological sample has the appropriate bioactive ingredients. This marker can also be used to identify a specific species.

Boster Bio: Anti-USP16 Marker

The USP16 Marker is a regulatory requirement for pharmaceuticals containing at least one tumor-specific mutation. To qualify, the tumor-specific mutation must be a drug-resistance mutation, such as BTK/C481S, EGFR/T790M, BCR-Abl/T315I, or BCR-ABL/Y253H. The marker must also contain at least one of the following: BTK/C481S, EGFR/T790M, BCR-Abl/T315I, c-kit/T670I, HER2/G776(YVMA), ALK/F1174C, BRAF/V600E, and PIK3CA/E545K.

Boster Bio: Using the USP16 Marker

When it comes to boster bio products, you can rest assured that you are getting the best quality for your money. Boster Bio products have been well cited for over 25 years and are trusted by scientists and researchers worldwide. Boster bio antibodies have been validated for use in immunohistochemistry, Western blotting and ELISA. So, no matter what your research goals are, Boster has the antibodies you need.