Uroplakin-2 Antibodies

AND UPK2 ELISA kits, Uroplakin-2 Proteins

Many biological assays use antibodies to detect Uroplakin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Uroplakin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Uroplakin-2 antibodies...

We validate the specificity of these antibodies to Uroplakin-2 by testing them on tissues known to express UPK2 positively and negatively. Browse below to find the UPK2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UPK2 Infographic by Boster Bio

All UPK2 Products

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Uroplakin II (UPK2) (NM_006760) Human Recombinant Protein

$1249
Cat # PROTO00526
20 µg

Uroplakin II (UPK2) (NM_006760) Human Over-expression Lysate

Human

$628
Cat # LS007379
100 µg

UPK2 Overview

Facts about Uroplakin-2.

UPK2 3D structure. Source: alphafold

Uroplakin-2 (UPK2)

Part of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an essential role in regulating the assembly of the AUM (By similarity).

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Gene Information

Human
Gene Name:	UPK2
Uniprot:	O00526
Entrez:	7379

Family

Belongs to:

uroplakin-2 family

Alternative Names

UP2; UPII; UPK2 uroplakin 2

Molecular Weight

Mass (kDA):
19.438 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (118956298..118958559)

Tissue Specificity

Expressed in ureter.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER).

Diseases

Carcinoma
Bladder Neoplasm
Neoplasms
Malignant Neoplasms
Carcinoma, Transitional Cell
Malignant Neoplasm Of Urinary Bladder
Neoplasm Metastasis
Cystitis
Hyperplasia
Cell Transformation, Neoplastic
Transitional Cell Carcinoma Of Bladder
Lymphatic Metastasis
Urologic Neoplasms

Inflammation
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Paraganglionic Neoplasm
Gastroesophageal Reflux Disease
Vesico-ureteral Reflux
Neoplasm Invasiveness
Carcinoma In Situ

Interacting Proteins

CCDC155

Pathways

Localization
Reverse Transcription
Pathogenesis
Micturition
Transport
Hypersensitivity
Wound Healing
Cell Proliferation
Regeneration
Secretion
Immune Response
Lymphangiogenesis
Chromosome Segregation

Reflex
Inflammatory Response
Cell Division
Translation
Cell Cycle
Telomere Maintenance
Cell Differentiation

PTMs

Phosphorylation
Glycosylation

Cleavage
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UPK2

References

PMID: 9846985 by Lobban E.D., et al. Uroplakin gene expression by normal and neoplastic human urothelium.

PMID: 12792753 by Hirata H., et al. Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction.