Uromodulin Antibodies

Uromodulin (UMOD)

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes creation of complex filamentous gel-like structure which may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215).

Facilitates neutrophil migration across renal epithelia (PubMed:20798515). .

Gene Information

Human
Gene Name:	UMOD
Uniprot:	P07911
Entrez:	7369

Family

Belongs to:
No superfamily

Alternative Names

ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; Tamm-Horsfall glycoprotein; Tamm-Horsfall urinary glycoprotein; THGP; THP; UMOD; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); Uromodulin; Uromucoid

Molecular Weight

Mass (kDA):
69.761 kDA

Genomic Context

Human
Location:	16p12.3
Sequence:	16; NC_000016.10 (20333051..20356301, complement)

Tissue Specificity

Expressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen.

Subcellular Localizations

Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane. Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860).; [Uromodulin, secreted form]: Secreted. Detected in urine.

Diseases

• Kidney Diseases
• Kidney Calculi
• Hyperuricemia
• Kidney Failure
• Kidney Failure, Chronic
• Urinary Tract Infection
• Hyperuricaemic Nephropathy
• Proteinuria Of Undiagnosed Cause
• Cystic Kidney Diseases
• Gout
• Nephritis
• Familial Juvenile Gout
• Nephrolithiasis

• Chronic Kidney Disease
• Medullary Cystic Disease
• Nephritis, Interstitial
• Diabetes Mellitus
• Infection Of Kidney
• Infective Disorder
• Gastroesophageal Reflux Disease

Pathways

• Excretion
• Pathogenesis
• Localization
• Transport
• Glomerular Filtration
• Secretion
• Glycosylation
• Cell Proliferation
• Virulence
• Phagocytosis
• Immune Response
• Cell Death
• Diuresis

• Inflammatory Response
• T Cell Proliferation
• Ion Transport
• Proteolysis
• Cell Adhesion
• Cell Activation
• Regeneration

PTMs

• Glycosylation
• Cleavage
• Deglycosylation
• Gpi Anchoring
• Reduction
• Methylation

• Phosphorylation
• Nitration
• Sulphation
• Carboxylation
• Hydroxylation
• Ubiquitination

• Acetylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UMOD

Best Uses Of The UMOD Marker

What is the UMOD Marker exactly? How can it be used and what is its purpose? Read on to learn more. The UMOD indicator is a biomarker of age-related changes to the kidney. This biomarker is closely tied to the structure of the kidney. You need to be able to use it to improve your patients' health. Boster Bio offers a comprehensive analysis of biomarkers.

UMOD Marker

The UMOD marker is a protein that has multiple functions, including the ability to detect cell death. Its ability induce ER stress-dependent and cellular apoptosis in cells can indicate its presence. Although the UMOD markers do not cause cancer, they may be useful in certain medical situations. However, it is not yet clear which applications it has in the body.

The UMOD marker is a high-molecular-weight mucoprotein that was isolated from human urine in 1952. This protein is only found in the renal epithelial cells, which are located in the early distal tubule and thick ascending leg of the loop. UMOD protein is glycosylated at seven of its eight potential N-glycosylation sites, anchored to the luminal surface of the tubule, and secreted into the urine at an estimated rate of 50 to 100 milligrams per day.

The UMOD Score is based upon biochemical, histological and imaging data. It is useful in guiding genetic testing. For instance, it can help identify which patients will benefit from specific testing and treatments. For example, a high score in patients suffering from CKD can predict if the patient will have the disease. Renal cysts are rare in ADTKD-UMOD.

The strong association between the UMOD and CKD risk was found. It has also been associated with various other diseases, including kidney stones and hypertension. In addition to being linked to kidney disease, UMOD also encodes a protein called uromodulin, which is excreted in the urine. Its gene variants might explain how the UMOD proteins contribute to overall kidney disease.

eGFR has been shown to be associated with levels of urinary UMOD. They have been associated with eGFR, which measures glomerular filtration rate. To make a more reliable comparison between patients and controls, the urinary levels of UMOD must be normalized to the eGFR. The UMOD score can be used for diagnosing UMOD muc1 and UMOD mutations in ADTKD MUC1.

Autophagy, which is the key mechanism to remove damaged organelles, components of the cytoplasm, and misfolded cells, is crucial. Autophagy also involves the degradation of scaffold proteins, including P62, which are associated with ubiquitin-binding. Clearance of these proteins is an indicator of active autophagy. So what are the Best Uses Of The UMOD Marker?

It is a biomarker for age-related changes in healthy kidneys

Recent research shows that UMOD is a biomarker of age-related changes in the healthy renal. Its variability in blood and urine is indicative of the kidney's functioning mass. It is strongly associated with renal function, cardiovascular events and overall mortality. The authors suggest that the UMOD gene variants could be useful tools for identifying early changes in kidney function.

Multidetector CT scans have been used to determine the UMOD levels of healthy kidneys. The number TAL segments was lower for healthy people than it was for those who were ill. This suggests that UMOD synthesis is not well represented in renal clinical pathology. It is possible that UMOD may play a role in the development of age-related kidney disease. Its oxidative stress leads to the induction or inhibition of cyclindependent kinase and the senescence of cortical tubular. It also contributes towards the chronic inflammatory reaction, which leads to the accumulation macrophages and lymphocytes within the interstitium. This results in the development of tubular atrophy and interstitial fibrosis, which are hallmarks of age-related kidney

Older people are the best to study the phenotypes of UMOD in healthy kidneys. The researchers examined a subgroup of elderly participants who had genotype information. The genotypes of the participants were derived from Affymetrix SNP Array 6.0 analyses. They also measured the participants' estimated GFR. The eGFR was calculated based on a one-time measurement of serum creatinine.

The study suggests that UMOD could be used as a biomarker to detect age-related changes in healthy kidneys. Its increased expression may be a sign of age-related kidney changes. These results should be confirmed by further studies. Understanding UMOD in healthy kidneys is essential.

The healthy kidney has many functions for UMOD. It plays a vital role in the normal functioning of the kidney, including protecting against urinary tract infections, protecting against renal stones, and regulating renal ion flow. It may also have a systemic antioxidant role. These roles of UMOD in the kidney have considerable translational significance. UMOD, just like many other age-related biomarkers in the kidney, is a biomarker to help with the aging process.

The US Food and Drug Administration (FDA), has a list with qualified renal biomarkers that can be used in clinical trials. UMOD provides additional information to serum creatinine and is considered a viable alternative to these biomarkers. However, most of the studies involved healthy adult volunteers and male rats. The FDA has created a formal regulatory process for UMOD to provide regulatory advice. The biomarker qualification process is used to develop drugs that are appropriate for patients with renal disease or special demographics.

It is tied to structural integrity

Recent research has shown that the UMOD marker is associated with kidney structural integrity. It was previously thought that it was located at the apical tube, but recent research has linked it to intracellular structure. In normal kidneys, UMOD expression is associated with an increase in glomeruli and distal convoluted tubeules. A recent study found that the UMOD marker is highly expressed in tubule apical and intracellular basement membranes in healthy subjects.

Molecular analysis revealed that UMOD and structural integrity are closely linked in aging. The expression of UMOD is more pronounced as the GFR decreases but Umod synthesis remains constant. Understanding the mechanisms behind the age-related changes in healthy kidneys is possible by understanding the link between UMOD (structural integrity) and UMOD (expression). Additional mutations in this gene could be identified, which could explain approximately half of cases of UMOD-related diseases.

The kidneys contain a high amount of the UMOD protein, which is a major cause of chronic kidney disease. A growing body of evidence has suggested that UMOD is involved in the process of chronic tubulointerstitial damage. Genetically normal human UMOD does not contribute to the prevention or propagation of chronic kidney disease. Despite these implications, UMOD has received renewed attention in recent years.

Researchers have demonstrated that UMOD gene is closely linked with structural integrity using F4/80 monoocyte/macrophage marker. Although this association could have other effects, it is not clear why the UMOD marker has been linked to structural integrity. It could be due to the expressions of RANTES. However, this is not enough to support the association.