BRCA1-A complex subunit RAP80 (Uimc1)

Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19536136).

Plays a central role in the BRCA1-A complex by specifically binding'Lys-63'- linked ubiquitinated histones H2A and H2AX in DNA lesions sites, leading to goal the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes'Lys- 63'-linked ubiquitin on histones H2A and H2AX.