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- Table of Contents
Facts about BRCA1-A complex subunit RAP80.
Plays a central role in the BRCA1-A complex by specifically binding'Lys-63'- linked ubiquitinated histones H2A and H2AX in DNA lesions sites, leading to goal the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes'Lys- 63'-linked ubiquitin on histones H2A and H2AX.
Mouse | |
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Gene Name: | Uimc1 |
Uniprot: | Q5U5Q9 |
Entrez: | 20184 |
Belongs to: |
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RAP80 family |
BRCA1-A complex subunit RAP80; RAP80; RAP80X2HRIP110; receptor associated protein 80; Receptor-associated protein 80; retinoid x receptor interacting protein; Retinoid X receptor-interacting protein 110; RXRIP110; ubiquitin interaction motif containing 1; Ubiquitin interaction motif-containing protein 1; UIMC1; X2HRIP110
Mass (kDA):
81.478 kDA
Mouse | |
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Location: | 13|13 B1 |
Sequence: | 13; |
PMID: 7760852 by Seol W., et al. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.
PMID: 12954732 by Kim Y.-S., et al. Tsp57: a novel gene induced during a specific stage of spermatogenesis.