UGT1A4 Antibodies

AND UGT1A4 ELISA kits, UGT1A4 Proteins

Many biological assays use antibodies to detect UGT1A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UGT1A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UGT1A4 antibodies...

We validate the specificity of these antibodies to UGT1A4 by testing them on tissues known to express UGT1A4 positively and negatively. Browse below to find the UGT1A4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UGT1A4 Infographic by Boster Bio

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UGT1A4 (NM_007120) Human Over-expression Lysate

Human

$960
Cat # LS054657
100 µg

UGT1A4 Overview

Facts about UDP-glucuronosyltransferase 1-4.

UGT1A4 3D structure. Source: alphafold

UDP-glucuronosyltransferase 1-4 (UGT1A4)

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). .

Gene Information

Human
Gene Name:	UGT1A4
Uniprot:	P22310
Entrez:	54657

Family

Belongs to:

UDP-glycosyltransferase family

Alternative Names

bilirubin UDP-glucuronosyltransferase isozyme 2; Bilirubin-specific UDPGT isozyme 2; GNT1; HUG-BR2; polypeptide A4; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1-4; UDP-glucuronosyltransferase 1A4; UDP-glucuronosyltransferase 1-D; UDPGT 1-4; UDPGT; UGT1; UGT1*4; UGT1.4; UGT1-04; UGT-1D; UGT1DEC 2.4.1.17

Molecular Weight

Mass (kDA):
60.025 kDA

Genomic Context


Human

Location:	2q37.1
Sequence:	2; NC_000002.12 (233718736..233773300)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin.

Subcellular Localizations

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Carcinoma
Schizophrenia
Carcinogenesis
Liver Carcinoma
Epilepsy
Myeloproliferative Syndrome, Transient
Neoplasms
Liver Diseases
Liver Neoplasms
Malignant Neoplasm Of Urinary Bladder
Immunologic Deficiency Syndromes

Dysequilibrium Syndrome
Colorectal Cancer
Bipolar Disorder
Mammary Neoplasms
Diabetes Mellitus
Pregnancy Complications
Ulcer

Pathways

Conjugation
Excretion
Transport
Xenobiotic Glucuronidation
Sulfation
Lactation
Aging
Bilirubin Conjugation
Glomerular Filtration
Flight
Reverse Transcription

Translation
Cell Death
Dna Modification
Acyl Glucuronidation
Angiogenesis
Sos Response

PTMs

Hydroxylation
Demethylation

Carboxylation
Reduction

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UGT1A4

References

PMID: 1898728 by Ritter J.K., et al. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

PMID: 1339448 by Ritter J.K., et al. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.