UBR2 Antibodies

AND UBR2 ELISA kits, UBR2 Proteins

Many biological assays use antibodies to detect UBR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBR2 antibodies...

We validate the specificity of these antibodies to UBR2 by testing them on tissues known to express UBR2 positively and negatively. Browse below to find the UBR2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBR2 Infographic by Boster Bio

All UBR2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-UBR2 Picoband® Antibody

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05812-2
100 μg/vial

Anti-UBR2 Antibody

Human, Mouse, Rat

$405
Cat # A05812
100ul

Anti-UBR2 Picoband® Antibody (monoclonal, 2G10)

Human

$370
Cat # M05812
100 μg/vial

UBR2 Overview

Facts about E3 ubiquitin-protein ligase UBR2.

UBR2 3D structure. Source: alphafold

E3 ubiquitin-protein ligase UBR2 (UBR2)

E3 ubiquitin-protein ligase that is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues which are destabilizing in line with the N-end rule, resulting in their ubiquitination and subsequent degradation.

Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis through ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Gene Information

Human
Gene Name:	UBR2
Uniprot:	Q8IWV8
Entrez:	23304

Family

Belongs to:

UBR1 family

Alternative Names

bA49A4.1; C6orf133MGC71112; chromosome 6 open reading frame 133; dJ242G1.1; dJ392M17.3; DKFZp686C08114; E3 ubiquitin-protein ligase UBR2; EC 6.3.2.-; KIAA0349FLJ36357; N-recognin-2; RP3-392M17.3; ubiquitin protein ligase E3 component n-recognin 2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II

Molecular Weight

Mass (kDA):
200.538 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (42563954..42693505)

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).

Subcellular Localizations

Nucleus. Associated with chromatin during meiosis.

Diseases

Infertility
Malignant Neoplasms
Johanson-blizzard Syndrome
Neurodegenerative Disorders
Instabilities, Chromosomal
Sclerosis
Exocrine Pancreatic Insufficiency
Primary Lateral Sclerosis
Malignant Neoplasm Of Breast
Anosmia
Hypoxia
Amyotrophic Lateral Sclerosis
Immunologic Deficiency Syndromes

Tumor Angiogenesis
Neoplasms
Azoospermia
Mammary Neoplasms
Acute Interstitial Pneumonia
Adenocarcinoma
Liver Carcinoma

Pathways

Meiosis
Pachytene
Spermatogenesis
Proteolysis
Prophase
Hypersensitivity
Male Meiosis
S Phase
Pathogenesis
Histone Ubiquitination
Aging
Neurogenesis
Histone Modification

Nutrient Import
Cell Cycle
Meiosis I
Chromatin Remodeling
Recombinational Repair
Cell Proliferation
Meiotic Prophase I

PTMs

Phosphorylation
Ubiquitination

Reduction
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBR2

References

PMID: 15548684 by Kwak K.S., et al. Regulation of protein catabolism by muscle-specific and cytokine- inducible ubiquitin ligase E3alpha-II during cancer cachexia.

PMID: 15317757 by Yin J., et al. RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.