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- Table of Contents
Facts about Ubiquitin-conjugating enzyme E2 S.
Acts as an important factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle- regulated ubiquitin ligase that controls progression through mitosis. Acts by especially elongating'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151).
Human | |
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Gene Name: | UBE2S |
Uniprot: | Q16763 |
Entrez: | 27338 |
Belongs to: |
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ubiquitin-conjugating enzyme family |
E2-24K; E2-EPF; E2-EPF5; E2-EPF52; E2-EPFEC 6.3.2.19; E2EPFEPF5; EPF5; UBE2S; Ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2 S; ubiquitin-conjugating enzyme E2-24 kD; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; ubiquitin-conjugating enzyme E2S; Ubiquitin-protein ligase S
Mass (kDA):
23.845 kDA
Human | |
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Location: | 19q13.42 |
Sequence: | 19; NC_000019.10 (55399745..55408439, complement) |
PMID: 1379239 by Liu Z., et al. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.
PMID: 16819549 by Jung C.R., et al. E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.