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UBE2L6 Antibodies
AND UBE2L6 ELISA kits, UBE2L6 Proteins
Many biological assays use antibodies to detect UBE2L6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2L6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2L6 antibodies...
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UBE2L6 Infographic by Boster Bio
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UBE2L6 Overview
Facts about Ubiquitin/ISG15-conjugating enzyme E2 L6.
Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6)
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions at the E6/E6-AP-induced ubiquitination of p53/TP53.
Promotes ubiquitination and subsequent proteasomal degradation of FLT3. .
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2L6 |
| Uniprot: | O14933 |
| Entrez: | 9246 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
EC 6.3.2.19; retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG-B; UbcH8; UBCH8MGC40331; UBE2L6; Ubiquitin carrier protein L6; ubiquitin/ISG15-conjugating enzyme E2 L6; ubiquitin-conjugating enzyme E2L 6; Ubiquitin-protein ligase L6
Molecular Weight
Mass (kDA):
17.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.1 |
| Sequence: | 11; NC_000011.10 (57551655..57568330, complement) |
Tissue Specificity
Present in natural killer cells (at protein level).
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Leukemia
- Malignant Neoplasm Of Breast
- Influenza
- Virus Diseases
- Inflammation
- Neoplasm Metastasis
- Malignant Neoplasm Of Kidney
- Inflammatory Bowel Diseases
- Alphavirus Infections
Interacting Proteins
- ARIH2
- DTX3
- LONRF1
- RBCK1
- RNF144B
- RNF19B
- Rnf40
- TRIM8
Pathways
- Conjugation
- Immune Response
- Cell Cycle
- Proteolysis
- Chromatin Remodeling
- Cell Migration
- Jnk Cascade
- Localization
- Rna Splicing
- Cell Maturation
- Cytoskeleton Organization
- Dna Replication
- Cytokine Production
PTMs
- Ubiquitination
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2L6
bosterbio.com/bosterbio-gene-info-cards/UBE2L6
References
PMID: 10894956 by Ardley H.C., et al. Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12.
PMID: 9153201 by Kumar S., et al. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.