Ubiquitin-conjugating enzyme E2 E2 (UBE2E2)

Accepts ubiquitin from the E1 complicated and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.

Catalyzes the ISGylation of influenza A virus NS1 protein. .