This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Ubiquitin-conjugating enzyme E2 C.
Acts as an important factor of the anaphase promoting complex/cyclosome (APC/C), a mobile cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating'Lys-11'-linked polyubiquitin chains on APC/C substrates, causing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Human | |
---|---|
Gene Name: | UBE2C |
Uniprot: | O00762 |
Entrez: | 11065 |
Belongs to: |
---|
ubiquitin-conjugating enzyme family |
cyclin-selective ubiquitin carrier protein; dJ447F3.2; EC 6.3.2.19; UbcH10; UBCH10mitotic-specific ubiquitin-conjugating enzyme; UBE2C; Ubiquitin carrier protein C; ubiquitin carrier protein E2-C; ubiquitin-conjugating enzyme E2 C; ubiquitin-conjugating enzyme E2C; Ubiquitin-protein ligase C
Mass (kDA):
19.652 kDA
Human | |
---|---|
Location: | 20q13.12 |
Sequence: | 20; NC_000020.11 (45812576..45816957) |
PMID: 9122200 by Townsley F.M., et al. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase.
PMID: 15558010 by Rape M., et al. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.