Ubiquitin-conjugating enzyme E2 C (UBE2C)

Accepts ubiquitin from the E1 complicated and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination.

Acts as an important factor of the anaphase promoting complex/cyclosome (APC/C), a mobile cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating'Lys-11'-linked polyubiquitin chains on APC/C substrates, causing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.