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UBE2B Antibodies
AND UBE2B ELISA kits, UBE2B Proteins
Many biological assays use antibodies to detect UBE2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2B antibodies...
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UBE2B Infographic by Boster Bio
All UBE2B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M05190
100 µl
Cat # M05190
100 µl
UBE2B Overview
Facts about Ubiquitin-conjugating enzyme E2 B.
Ubiquitin-conjugating enzyme E2 B (UBE2B)
Accepts ubiquitin in the E1 complicated and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B in'Lys-120' to form H2BK120ub1.
H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2B |
| Uniprot: | P63146 |
| Entrez: | 7320 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
E2 protein; E2-17k; E2-17kDa; HHR6B; HR6B; RAD6 homolog B; RAD6BEC 6.3.2.19; UBC2; UBE2B; Ubiquitin carrier protein B; ubiquitin-conjugating enzyme E2 B; Ubiquitin-conjugating enzyme E2-17 kDa; ubiquitin-conjugating enzyme E2B (RAD6 homolog); Ubiquitin-protein ligase B
Molecular Weight
Mass (kDA):
17.312 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (134371569..134392108) |
Subcellular Localizations
Cell membrane. Nucleus. In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Diseases
- Infertility
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Male Infertility
- Carcinoma
- Neoplasms
- Muscular Atrophy
- Atrophy
- Cholangiocarcinoma
- Monosomy
- Complete Trisomy 18 Syndrome
- Glaucoma, Open-angle
Interacting Proteins
- HIST3H2A
- RAD18
- UBR1
Pathways
- Dna Repair
- Sporulation
- Spermatogenesis
- Postreplication Repair
- Prophase
- Pachytene
- Translesion Synthesis
- Cell Cycle
- Meiosis
- Methylation
- Histone Ubiquitination
- Chromatin Modification
- Chromatin Remodeling
PTMs
- Ubiquitination
- Methylation
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2B
bosterbio.com/bosterbio-gene-info-cards/UBE2B
References
PMID: 2158443 by Schneider R., et al. The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6.
PMID: 1883845 by Woffendin C., et al. Mammalian mRNAs encoding protein closely related to ubiquitin- conjugating enzyme encoded by yeast DNA repair gene RAD6.