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UBA2 Antibodies
AND UBA2 ELISA kits, UBA2 Proteins
Many biological assays use antibodies to detect UBA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBA2 antibodies...
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UBA2 Infographic by Boster Bio
All UBA2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A03816-2
100 μg/vial
Cat # A03816-2
100 μg/vial
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03816
100 μl
Cat # M03816
100 μl
Human
ELISA
$480
Cat # EKC1584
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1584
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M03816-1
100 μg/vial
Cat # M03816-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M03816-2
100 μg/vial
Cat # M03816-2
100 μg/vial
UBA2 Overview
Facts about SUMO-activating enzyme subunit 2.
SUMO-activating enzyme subunit 2 (UBA2)
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4.
It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2..
Gene Information
| Human | |
|---|---|
| Gene Name: | UBA2 |
| Uniprot: | Q9UBT2 |
| Entrez: | 10054 |
Family
| Belongs to: |
|---|
| ubiquitin-activating E1 family |
Alternative Names
Anthracycline-associated resistance ARX; ARX; EC 6.3.2; EC 6.3.2.-; FLJ13058; HRIHFB2115; SAE2SUMO-1 activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1 homolog; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; UBLE1B
Molecular Weight
Mass (kDA):
71.224 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.11 |
| Sequence: | 19; NC_000019.10 (34428176..34471251) |
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Diseases
- Malignant Neoplasms
- Acute Promyelocytic Leukemia
- Leukemia
- Carcinoma
- Dysplasia
- Neoplasms
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Hiv Infections
- Hyperplasia
- Radiation Injury
- Dermatomyositis
- Hepatitis B
Interacting Proteins
- SAE1
- SUMO1
- SUMO1P1
- UBE2I
Pathways
- Conjugation
- Localization
- Cell Cycle
- Mitosis
- Dna Repair
- Protein Sumoylation
- Proteolysis
- Hypersensitivity
- Nuclear Import
- Dna Replication
- Cell Death
- Pathogenesis
- Rna Interference
PTMs
- Sumoylation
- Ubiquitination
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBA2
bosterbio.com/bosterbio-gene-info-cards/UBA2
References
PMID: 9920803 by Okuma T., et al. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.
PMID: 10217437 by Gong L., et al. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.