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- Table of Contents
Facts about Tribbles homolog 1.
Serves to change COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797).
Human | |
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Gene Name: | TRIB1 |
Uniprot: | Q96RU8 |
Entrez: | 10221 |
Belongs to: |
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protein kinase superfamily |
C8FWG-protein-coupled receptor induced protein; GIG-2; GIG2G-protein-coupled receptor-induced protein 2; G-protein-coupled receptor-induced gene 2 protein; SKIP1; TRB-1; TRB1phosphoprotein regulated by mitogenic pathways; tribbles homolog 1 (Drosophila); tribbles homolog 1; tribbles-like protein 1
Mass (kDA):
41.009 kDA
Human | |
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Location: | 8q24.13 |
Sequence: | 8; NC_000008.11 (125430290..125438405) |
Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.
PMID: 15299019 by Kiss-Toth E., et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
PMID: 9342215 by Wilkin F., et al. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.