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- Table of Contents
Facts about Tumor necrosis factor receptor superfamily member 22.
Receptor for the cytotoxic ligand TNFSF10/TRAIL.
Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis.Protects cells from TRAIL mediated apoptosis possibly through ligand competition. Can't induce the NF-kappa-B pathway.
Mouse | |
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Gene Name: | Tnfrsf22 |
Uniprot: | Q9ER62 |
Entrez: | 79202 |
Belongs to: |
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No superfamily |
DcTRAIL R2; DcTRAILR2; SOBa; TNFRH2; TNFRSF22
Mass (kDA):
22.375 kDA
Mouse | |
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Location: | 7 F5|7 88.27 cM |
Sequence: | 7; |
Ubiquitous.
PMID: 11063728 by Engemann S., et al. Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
PMID: 12466268 by Schneider P., et al. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor- related apoptosis-inducing ligand (TRAIL).