Tnfrsf19 Antibodies

Tumor necrosis factor receptor superfamily member 19 (Tnfrsf19)

Can mediate activation of c-Jun and NF-kappa-B. May encourage caspase-independent cell death (By similarity).

Isoform 2 and isoform 3 may act as decoy receptors. .

Gene Information

Mouse
Gene Name:	Tnfrsf19
Uniprot:	Q9JLL3
Entrez:	29820

Family

Belongs to:
No superfamily

Alternative Names

TAJ; TAJ-alpha; TAJToxicity and JNK inducer; TNFRSF19; TRADE; TROY; TROYtumor necrosis factor receptor superfamily member 19; tumor necrosis factor receptor superfamily, member 19

Molecular Weight

Mass (kDA):
45.265 kDA

Genomic Context

Mouse
Location:	14|14 D1
Sequence:	14;

Diseases

• Nervousness
• Sclerosis
• Dysplasia
• Multiple Sclerosis
• Spinal Cord Injuries
• Glioma
• Carcinoma
• Neoplasms
• Lymphoma
• Hyperplastic Polyp
• Cell Invasion
• Skin Neoplasms
• Glioblastoma

• Ectodermal Dysplasia
• Leukemia
• Melanoma
• Dementia
• Malignant Neoplasm Of Brain
• Myeloid Leukemia, Chronic
• Neoplasm Invasiveness

Pathways

• Regeneration
• Axon Regeneration
• Cell Death
• Hair Follicle Development
• Neurogenesis
• Cell Migration
• Cell Proliferation
• Programmed Cell Death
• Osteoblast Differentiation
• Cell Development
• Brain Development
• Muscle Contraction
• Reflex

• Glial Cell Development
• Organ Development
• Gliogenesis
• Chromatin Organization
• Angiogenesis
• Regulation Of Gliogenesis
• Eye Development

PTMs

• Phosphorylation

Research Areas

• Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tnfrsf19

Boster Bio - Best Uses Of The TNFRSF19 Marker

High-affinity primaries antibodies are crucial to the study of TNFRSF19. Boster Bio provides these antibodies for special samples and various applications. You can submit your species or application results and receive credit for the research. These credits are open to all scientists worldwide. This article will cover the benefits of Boster primary antibodies. In this article, we will discuss how these antibodies work in biological research.

Boster Bio supplies high-affinity primary antibody products

Boster Bio stocks high-affinity primaries against the TNFSSF19 mark. The antibodies are composed of two polypeptides. One is heavy and one is light. Both chains are linked by disulfide bond. The antibodies are good for one year at temperatures of -20°C. They can be freeze-dried for six months or longer. Boster Bio's antibodies have undergone rigorous validation.

To increase affinity, several engineered FcRn variants were developed. Transgenic mice have shown increased serum half-life and affinity for the M428L/N434S or M252Y/S254T/T256E variations. Clinical trials are being performed to determine the YTE variant of the antibody. Its enhanced affinity for TNFRSF19 as well as the FcRn subunits make it compatible with the p53-receptor system of human cells.

EDH (EDHY), TEDHY, as well as EDH, have been proven to be highly specific and sensitive antibodies against TNFRSF19. In this assay, the binding activities of the TEDHY and EDHY variants were significantly higher than those of wild-type IgG1. Both variants have high MFI compared to wild-type IgG1.

The TNFRSF19 antibody is made from polypeptides that have been expressed in the host cell. The antibody is composed of a heavy- and a light-chain. The mutations in the heavy chains of the antibody can cause binding to FcRn to be affected. High affinity to FcRn will be achieved if the antibodies have the same heavy and light chains.