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- Table of Contents
Facts about Tumor necrosis factor receptor superfamily member 14.
Receptor for BTLA.
Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha.Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of numerous wild-type HSV strains of both serotypes to CHO cells, and mediated HSV entry into activated human T-cells.
Human | |
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Gene Name: | TNFRSF14 |
Uniprot: | Q92956 |
Entrez: | 8764 |
Belongs to: |
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tumor necrosis factor receptor superfamily |
ATAR; CD270 antigen; CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; HVEM; HVEMTR2HVEAATAR; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Mass (kDA):
30.392 kDA
Human | |
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Location: | 1p36.32 |
Sequence: | 1; NC_000001.11 (2556365..2565622) |
Widely expressed, with the highest expression in lung, spleen and thymus.
Cell membrane; Single-pass type I membrane protein.
PMID: 8898196 by Montgomery R.I., et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family.
PMID: 9162061 by Kwon B.S., et al. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation.