TNFRSF11B Antibodies

AND TNFRSF11B ELISA kits, TNFRSF11B Proteins

Many biological assays use antibodies to detect TNFRSF11B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFRSF11B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFRSF11B antibodies...

We validate the specificity of these antibodies to TNFRSF11B by testing them on tissues known to express TNFRSF11B positively and negatively. Browse below to find the TNFRSF11B antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNFRSF11B Infographic by Boster Bio

All TNFRSF11B Products

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Product

Figures

Specificity

Applications

Price

Human OPG (TNFRSF11B) / Osteoprotegerin ELISA Kit PicoKine®

30 Citations 10 Q&As

Human

ELISA

$499
Cat # EK0480
96 wells/kit, with removable strips.

Mouse OPG (TNFRSF11B) / Osteoprotegerin ELISA Kit PicoKine®

27 Citations 12 Q&As

Mouse

ELISA

$499
Cat # EK0481
96 wells/kit, with removable strips.

Mouse OPG (TNFRSF11B) / Osteoprotegerin PicoKine® Quick ELISA Kit

1 Citations 2 Q&As

Mouse

ELISA

$499
Cat # FEK0481
96 wells/kit, with removable strips.

Anti-Osteoprotegerin/TNFRSF11B Antibody Picoband®

5 Citations 1 Q&As

+21

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00863
100 μg/vial

Human Osteoprotegerin/TNFRSF11B Recombinant Protein

SDS-PAGE

$250
Cat # PROTO00300
Starting from 10ug

Mouse Osteoprotegerin/TNFRSF11B Recombinant Protein

SDS-PAGE

$265
Cat # PROTO08712
Starting from 10ug

Anti-Osteoprotegerin Rabbit Monoclonal Antibody

Human

IF, IHC, ICC

$370
Cat # M00863-1
100 μl/vial

Osteoprotegerin (TNFRSF11B) (NM_002546) Human Over-expression Lysate

Human

$628
Cat # LS004982
100 µg

TNFRSF11B Overview

Facts about Tumor necrosis factor receptor superfamily member 11B.

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Acts as decoy receptor for TNFSF11/RANKL and thus neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.

Bone homeostasis appears to be based on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification.

Gene Information

Human
Gene Name:	TNFRSF11B
Uniprot:	O00300
Entrez:	4982

Family

Belongs to:

No superfamily

Alternative Names

OCIF; OCIFMGC29565; OPGtumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily, member 11b

Molecular Weight

Mass (kDA):
46.026 kDA

Genomic Context


Human

Location:	8q24.12
Sequence:	8;

Tissue Specificity

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Subcellular Localizations

Secreted.

Diseases

Osteoporosis
Osteopenia
Bone Diseases
Arthritis
Malignant Neoplasms
Osteolysis
Neoplasms
Inflammation
Rheumatoid Arthritis
Fracture
Bone Neoplasms
Neoplasm Metastasis
Metabolic Bone Disorder

Multiple Myeloma
Osteoporosis, Postmenopausal
Vascular Calcification
Calcinosis
Metastatic Malignant Neoplasm To The Bone
Osteitis Deformans
Diabetes Mellitus

Interacting Proteins

TNFSF11

Pathways

Bone Resorption
Osteoclast Differentiation
Bone Remodeling
Pathogenesis
Secretion
Cell Proliferation
Osteoblast Differentiation
Excretion
Osteoclast Development
Localization
Protein Secretion
Menopause
Cell Differentiation

Regulation Of Bone Resorption
Osteoclast Maturation
Cell Death
Cell Growth
Regeneration
Bone Development
Aging

PTMs

Phosphorylation
Cleavage
Reduction
Glycosylation
Ubiquitination

Carboxylation
Gamma-carboxylation
Decarboxylation
Acetylation
Methylation

Prenylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF11B

References

PMID: 9108485 by Simonet W.S., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

PMID: 9492069 by Yasuda H., et al. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.

59 Publications of Boster TNFRSF11B Antibodies & ELISA Kits

PubMed ID: 10.3390/molecules24020271, Cajanolactone A from Cajanus cajan Promoted Osteoblast Differentiation in Human ...
PubMed ID: 10.3390/ijms20246321, Changes in Adipose Tissue Distribution and Association between Uric Acid and Bon...
PubMed ID: 10.3389/fphar.2018.01286, Effects of Taxifolin on Osteoclastogenesis in vitro and in vivo
PubMed ID: 10.3389/fcell.2021.640867, Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis a...
PubMed ID: 10.3109/13880209.2015.1017885, Anti-osteoporotic activity of puerarin 6″-O-xyloside on ovariectomized mice an...
PubMed ID: 10.2147/DDDT.S328238, Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Form...
PubMed ID: 10.18632/oncotarget.14071, Loss of RUNX3 expression inhibits bone invasion of oral squamous cell carcinoma
PubMed ID: 10.18632/oncotarget.12763, An in vitro 3D bone metastasis model by using a human bone tissue culture and hu...
PubMed ID: 10.1186/s12887-017-0820-1, Premature atherosclerosis in children with beta-thalassemia major: New diagnosti...
PubMed ID: 10.1186/1471-2474-13-191, Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of p...
PubMed ID: 10.1111/j.1744-9987.2012.01097.x, Serum Receptor Activator of Nuclear Factor‐κ B Ligand, Osteoprotegrin, and In...
PubMed ID: 10.1097/MAT.0000000000000796, Coupled OPG-Fc on Decellularized Aortic Valves by EDC/NHS Attenuates Rat MSCs Ca...
PubMed ID: 10.1096/fj.201600825RRR, REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced b...
PubMed ID: 10.1080/09513590.2017.1323205, VDR, RANKL and OPG polymorphisms as possible predisposing cofactors of postmenop...
PubMed ID: 10.1039/C5TB01956G, Alendronate-loaded hydroxyapatite-TiO2 nanotubes for improved bone formation in ...
PubMed ID: 10.1038/srep13575, Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Lo...
PubMed ID: 10.1038/s41598-019-50336-4, Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinso...
PubMed ID: 10.1038/s41419-020-2314-6, NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthrit...
PubMed ID: 10.1038/leu.2015.259, Osteolytic lesions, cytogenetic features and bone marrow levels of cytokines and...
PubMed ID: 10.1016/j.yexcr.2017.02.018, Lipoxin A4 suppresses osteoclastogenesis in RAW264.7 cells and prevents ovariect...
PubMed ID: 10.1016/j.msec.2018.08.069, Nanostructured titanium surfaces fabricated by hydrothermal method: Influence of...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page